Assay Detail
Binding
CHEMBL4193718
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human His-tagged c-Met cytoplasmic domain (956 to 1390 residues) expressed in baculovirus expression system using poly (Glu,Tyr)4:1 as substrate after 60 mins by spectrophotometric analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of the First c-Met/HDAC Inhibitors Based on Pyridazinone Derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.88 | 9.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4214018 | — | — | 1 | 9.36 |
| CHEMBL4209174 | — | — | 1 | 9.27 |
| CHEMBL4207111 | — | — | 1 | 9.20 |
| CHEMBL4204833 | — | — | 1 | 9.15 |
| CHEMBL4204308 | — | — | 1 | 9.14 |
| CHEMBL3417489 | — | — | 1 | 9.08 |
| CHEMBL4205747 | — | — | 1 | 9.02 |
| CHEMBL4209005 | — | — | 1 | 9.02 |
| CHEMBL4209562 | — | — | 1 | 9.00 |
| CHEMBL4208236 | — | — | 1 | 9.00 |
| CHEMBL4207710 | — | — | 1 | 8.96 |
| CHEMBL4203363 | — | — | 1 | 8.92 |
| CHEMBL4209189 | — | — | 1 | 8.89 |
| CHEMBL4218410 | — | — | 1 | 8.82 |
| CHEMBL4204322 | — | — | 1 | 8.43 |
| CHEMBL4210834 | — | — | 1 | 8.29 |
| CHEMBL4216512 | — | — | 1 | 7.43 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | - |
| CHEMBL3621988 | TUCIDINOSTAT | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4214018 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL4209174 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL4207111 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL4204833 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL4204308 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL3417489 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL4205747 | — | IC50 | = | 0.96 | nM | 9.02 |
| CHEMBL4209005 | — | IC50 | = | 0.96 | nM | 9.02 |
| CHEMBL4209562 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4208236 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4207710 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4203363 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4209189 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4218410 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4204322 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4210834 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL4216512 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL98 | VORINOSTAT | IC50 | - | — | - | |
| CHEMBL3621988 | TUCIDINOSTAT | IC50 | - | — | - |