Assay Detail
Binding
CHEMBL4193731
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Displacement of [3H]-DPCPX from human A1 receptor expressed in HEK293 cell membranes after 90 mins radioligand binding assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Potent and Selective A2A Antagonists with Efficacy in Animal Models of Parkinson's Disease and Depression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.61 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4215754 | — | — | 1 | 5.77 |
| CHEMBL4205341 | — | — | 1 | 5.77 |
| CHEMBL4212278 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4215754 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL4205341 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL4212278 | — | Ki | = | 5000.0 | nM | 5.30 |