Assay Detail
Binding
CHEMBL4193818
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from MOR in Wistar rat whole brain membranes after 45 mins by liquid scintillation counting method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cyclic Biphalin Analogues Incorporating a Xylene Bridge: Synthesis, Characterization, and Biological Profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.75 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200199 | BIPHALIN | — | 1 | 9.10 |
| CHEMBL4213910 | — | — | 1 | 8.88 |
| CHEMBL4209510 | — | — | 1 | 8.79 |
| CHEMBL4204649 | — | — | 1 | 8.76 |
| CHEMBL4217792 | — | — | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200199 | BIPHALIN | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL4213910 | — | Ki | = | 1.33 | nM | 8.88 |
| CHEMBL4209510 | — | Ki | = | 1.61 | nM | 8.79 |
| CHEMBL4204649 | — | Ki | = | 1.73 | nM | 8.76 |
| CHEMBL4217792 | — | Ki | = | 6.06 | nM | 8.22 |