Assay Detail
Binding
CHEMBL4193845
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Inhibition of full-length KDM4C (unknown origin) expressed in human KYSE-150 cells assessed as increase in H3K36me3 level after 24 hrs by Western blot analysis
6
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.59 | 8.89 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4216044 | — | — | 1 | 8.89 |
| CHEMBL4216399 | — | — | 1 | 7.72 |
| CHEMBL4207071 | — | — | 1 | 7.50 |
| CHEMBL4211946 | — | — | 2 | 6.25 |
| CHEMBL4202719 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4216044 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4216399 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4207071 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4211946 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4211946 | — | Inhibition | - | % | - | |
| CHEMBL4202719 | — | Inhibition | - | % | - |