Assay Detail
Binding
CHEMBL4193976
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Inhibition of bovine milk xanthine oxidoreductase pre-incubated for 3 mins followed xanthine substrate addition and measured every 1 mins for 10 mins by spectrophotometry
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and bioevaluation of 1-phenyl-pyrazole-4-carboxylic acid derivatives as potent xanthine oxidoreductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 8.04 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL172682 | — | — | 1 | 8.62 |
| CHEMBL169526 | — | — | 1 | 8.46 |
| CHEMBL4203776 | — | — | 1 | 8.38 |
| CHEMBL1164729 | FEBUXOSTAT | 4.0 | 1 | 8.28 |
| CHEMBL4208142 | — | — | 1 | 8.24 |
| CHEMBL4217468 | — | — | 1 | 8.24 |
| CHEMBL4213055 | — | — | 1 | 8.17 |
| CHEMBL4212512 | — | — | 1 | 8.11 |
| CHEMBL4205230 | — | — | 1 | 7.97 |
| CHEMBL4208654 | — | — | 1 | 7.88 |
| CHEMBL4212094 | — | — | 1 | 7.64 |
| CHEMBL4217071 | — | — | 1 | 7.35 |
| CHEMBL4204327 | — | — | 1 | 7.22 |
| CHEMBL4203394 | — | — | 1 | - |
| CHEMBL4208265 | — | — | 1 | - |
| CHEMBL4207744 | — | — | 1 | - |
| CHEMBL4212653 | — | — | 1 | - |
| CHEMBL4205791 | — | — | 1 | - |
| CHEMBL4217496 | — | — | 1 | - |
| CHEMBL4216546 | — | — | 1 | - |
| CHEMBL4216000 | — | — | 1 | - |
| CHEMBL4207541 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL172682 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL169526 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4203776 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL1164729 | FEBUXOSTAT | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL4208142 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4217468 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4213055 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL4212512 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL4205230 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL4208654 | — | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL4212094 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4217071 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4204327 | — | IC50 | = | 59.6 | nM | 7.22 |
| CHEMBL4203394 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4208265 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4207744 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4212653 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4205791 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4217496 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4216546 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4216000 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4207541 | — | IC50 | > | 100.0 | nM | - |