Assay Detail
Binding
CHEMBL4193992
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Inhibition of human AChE pre-incubated for 6 mins before ATCI substrate addition and measured after 12 mins by DTNB reagent dependent UV-Vis spectrophotometry based Ellman's method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel deoxyvasicinone derivatives as potent multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.25 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4210020 | — | — | 1 | 8.39 |
| CHEMBL4205426 | — | — | 1 | 8.28 |
| CHEMBL4207101 | — | — | 1 | 8.12 |
| CHEMBL4203988 | — | — | 1 | 7.97 |
| CHEMBL4217666 | — | — | 1 | 7.88 |
| CHEMBL4202749 | — | — | 1 | 7.78 |
| CHEMBL4208322 | — | — | 1 | 7.67 |
| CHEMBL4208869 | — | — | 1 | 7.62 |
| CHEMBL4217746 | — | — | 1 | 7.60 |
| CHEMBL4207386 | — | — | 1 | 7.59 |
| CHEMBL4218829 | — | — | 1 | 7.51 |
| CHEMBL4217139 | — | — | 1 | 7.43 |
| CHEMBL4212275 | — | — | 1 | 7.33 |
| CHEMBL4212713 | — | — | 1 | 7.18 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.12 |
| CHEMBL4210517 | — | — | 1 | 6.92 |
| CHEMBL4214932 | — | — | 1 | 6.64 |
| CHEMBL4213147 | — | — | 1 | 6.51 |
| CHEMBL4205651 | — | — | 1 | 6.28 |
| CHEMBL4209420 | — | — | 1 | 6.25 |
| CHEMBL456881 | DEOXYVASICINONE | — | 1 | 4.20 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4210020 | — | IC50 | = | 4.09 | nM | 8.39 |
| CHEMBL4205426 | — | IC50 | = | 5.31 | nM | 8.28 |
| CHEMBL4207101 | — | IC50 | = | 7.61 | nM | 8.12 |
| CHEMBL4203988 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL4217666 | — | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL4202749 | — | IC50 | = | 16.8 | nM | 7.78 |
| CHEMBL4208322 | — | IC50 | = | 21.2 | nM | 7.67 |
| CHEMBL4208869 | — | IC50 | = | 24.1 | nM | 7.62 |
| CHEMBL4217746 | — | IC50 | = | 25.3 | nM | 7.60 |
| CHEMBL4207386 | — | IC50 | = | 25.9 | nM | 7.59 |
| CHEMBL4218829 | — | IC50 | = | 30.7 | nM | 7.51 |
| CHEMBL4217139 | — | IC50 | = | 36.7 | nM | 7.43 |
| CHEMBL4212275 | — | IC50 | = | 46.4 | nM | 7.33 |
| CHEMBL4212713 | — | IC50 | = | 66.6 | nM | 7.18 |
| CHEMBL95 | TACRINE | IC50 | = | 76.5 | nM | 7.12 |
| CHEMBL4210517 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4214932 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL4213147 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4205651 | — | IC50 | = | 528.0 | nM | 6.28 |
| CHEMBL4209420 | — | IC50 | = | 557.0 | nM | 6.25 |
| CHEMBL456881 | DEOXYVASICINONE | IC50 | = | 62500.0 | nM | 4.20 |
| CHEMBL140 | CURCUMIN | IC50 | - | — | - |