Assay Detail
Binding
CHEMBL4194334
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Inhibition of recombinant human full-length carbonic anhydrase 1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.80 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2070207 | — | — | 1 | 7.38 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL4212188 | — | — | 1 | 6.21 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.11 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 5.92 |
| CHEMBL4208348 | — | — | 1 | 5.37 |
| CHEMBL4204007 | — | — | 1 | 5.32 |
| CHEMBL4215693 | — | — | 1 | 5.27 |
| CHEMBL4207837 | — | — | 1 | 5.23 |
| CHEMBL4212738 | — | — | 1 | 5.19 |
| CHEMBL4203483 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2070207 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL4212188 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL4208348 | — | Ki | = | 4310.0 | nM | 5.37 |
| CHEMBL4204007 | — | Ki | = | 4830.0 | nM | 5.32 |
| CHEMBL4215693 | — | Ki | = | 5330.0 | nM | 5.27 |
| CHEMBL4207837 | — | Ki | = | 5930.0 | nM | 5.23 |
| CHEMBL4212738 | — | Ki | = | 6450.0 | nM | 5.19 |
| CHEMBL4203483 | — | Ki | = | 6610.0 | nM | 5.18 |