Assay Detail
Functional
CHEMBL4194451
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Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs by liquid scintillation counting method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antimalarial evaluation of artesunate-polyamine and trioxolane-polyamine conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.27 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 9.30 |
| CHEMBL4205016 | — | — | 1 | 9.22 |
| CHEMBL4205524 | — | — | 1 | 9.22 |
| CHEMBL4217237 | — | — | 1 | 9.22 |
| CHEMBL4213779 | — | — | 1 | 9.10 |
| CHEMBL4214291 | — | — | 1 | 9.10 |
| CHEMBL4209396 | — | — | 1 | 9.10 |
| CHEMBL4218712 | — | — | 1 | 9.05 |
| CHEMBL4217759 | — | — | 1 | 8.96 |
| CHEMBL1830032 | — | — | 1 | 8.55 |
| CHEMBL4209154 | — | — | 1 | 8.30 |
| CHEMBL4212555 | — | — | 1 | 8.21 |
| CHEMBL4212811 | — | — | 1 | 8.04 |
| CHEMBL4208833 | — | — | 1 | 7.96 |
| CHEMBL4210583 | — | — | 1 | 7.96 |
| CHEMBL4215412 | — | — | 1 | 7.52 |
| CHEMBL4214072 | — | — | 1 | 7.49 |
| CHEMBL4213553 | — | — | 1 | 7.23 |
| CHEMBL4218487 | — | — | 1 | 7.22 |
| CHEMBL4205722 | — | — | 1 | 7.12 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 5.74 |
| CHEMBL4214244 | — | — | 1 | - |
| CHEMBL4208197 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4205016 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4205524 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4217237 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4213779 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4214291 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4209396 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4218712 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4217759 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1830032 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4209154 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4212555 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL4212811 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL4208833 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4210583 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4215412 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4214072 | — | IC50 | = | 32.2 | nM | 7.49 |
| CHEMBL4213553 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4218487 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4205722 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 1828.0 | nM | 5.74 |
| CHEMBL4214244 | — | IC50 | - | — | - | |
| CHEMBL4208197 | — | IC50 | - | — | - |