Compound Detail
CHEMBL4215412
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O=C(NCCCN(CCCCCCCCCCN(CCCNC(=O)C1CCC2(CC1)OOC1(O2)C2CC3CC(C2)CC1C3)C(=O)C1CCC2(CC1)OOC1(O2)C2CC3CC(C2)CC1C3)C(=O)C1CCC2(CC1)OOC1(O2)C2CC3CC(C2)CC1C3)C1CCC2(CC1)OOC1(O2)C2CC3CC(C2)CC1C3
Basic Information
| ChEMBL ID | CHEMBL4215412 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ICKZETCRBNFESZ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
1447.9
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 7.52 | 7.29 | 30.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 30.0 | nM | 7.52 | Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodi... | 28988153 |
| Plasmodium falciparum | IC50 | = | 88.0 | nM | 7.06 | Antiplasmodial activity against chloroquine sensitive Plasmodium falciparum NF54... | 28988153 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28988153 | 10.1016/j.ejmech.2017.09.040 | Plasmodium falciparum | 2 |
| 28988153 | 10.1016/j.ejmech.2017.09.040 | Unchecked | 1 |
| 28988153 | 10.1016/j.ejmech.2017.09.040 | L6 | 1 |
Data from ChEMBL 36 via Core Engine