Assay Detail
Functional
CHEMBL4194741
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Cytotoxicity against human A375 cells harboring BRAF V600E mutant after 72 hrs by CellTiter-Glo assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Current Insights of BRAF Inhibitors in Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.93 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4204895 | — | — | 1 | 8.00 |
| CHEMBL4207519 | — | — | 1 | 6.70 |
| CHEMBL4212142 | — | — | 1 | 6.70 |
| CHEMBL1230020 | PLX-4720 | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4204895 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4207519 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4212142 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 500.0 | nM | 6.30 |