Assay Detail
Binding
CHEMBL4194784
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Inhibition of human p38alpha assessed as reduction in [gamma32P]ATP incorporation in to peptide substrate after 40 mins by scintillation counting method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.70 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514201 | TALMAPIMOD | 2.0 | 1 | 8.00 |
| CHEMBL320069 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514201 | TALMAPIMOD | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL320069 | — | IC50 | = | 3981.07 | nM | 5.40 |