Assay Detail
Functional
CHEMBL4194885
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MX1 cells incubated for 72 hrs by cell-titer Glo assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MX1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 7.83 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4212498 | — | — | 1 | 9.14 |
| CHEMBL4208129 | — | — | 1 | 8.89 |
| CHEMBL4215988 | — | — | 1 | 8.85 |
| CHEMBL4208136 | — | — | 1 | 8.85 |
| CHEMBL4212062 | — | — | 1 | 8.70 |
| CHEMBL4217457 | — | — | 1 | 8.47 |
| CHEMBL4204316 | — | — | 1 | 8.40 |
| CHEMBL4217818 | — | — | 1 | 8.33 |
| CHEMBL4214501 | — | — | 1 | 8.31 |
| CHEMBL4213481 | — | — | 1 | 8.26 |
| CHEMBL4218411 | — | — | 1 | 8.25 |
| CHEMBL4213045 | — | — | 1 | 8.15 |
| CHEMBL4215043 | — | — | 1 | 8.14 |
| CHEMBL4202833 | — | — | 1 | 8.11 |
| CHEMBL3987016 | MIVEBRESIB | 2.0 | 1 | 7.89 |
| CHEMBL4202497 | — | — | 1 | 7.82 |
| CHEMBL4203764 | — | — | 1 | 7.80 |
| CHEMBL3978817 | — | — | 1 | 7.77 |
| CHEMBL4206058 | — | — | 1 | 7.75 |
| CHEMBL4210131 | — | — | 1 | 7.72 |
| CHEMBL3903195 | — | — | 1 | 7.37 |
| CHEMBL4217560 | — | — | 1 | 7.24 |
| CHEMBL4208643 | — | — | 1 | 7.11 |
| CHEMBL4215025 | — | — | 1 | 6.85 |
| CHEMBL4207179 | — | — | 1 | 6.85 |
| CHEMBL4207708 | — | — | 1 | 6.85 |
| CHEMBL3904546 | — | — | 1 | 5.85 |
| CHEMBL4203377 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4212498 | — | EC50 | = | 0.72 | nM | 9.14 |
| CHEMBL4208129 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4215988 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4208136 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4212062 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4217457 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4204316 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4217818 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4214501 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4213481 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4218411 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4213045 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4215043 | — | EC50 | = | 7.3 | nM | 8.14 |
| CHEMBL4202833 | — | EC50 | = | 7.8 | nM | 8.11 |
| CHEMBL3987016 | MIVEBRESIB | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4202497 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4203764 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3978817 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4206058 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4210131 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3903195 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4217560 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4208643 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4215025 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4207179 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4207708 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3904546 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4203377 | — | EC50 | = | 3300.0 | nM | 5.48 |