Assay Detail
Binding
CHEMBL4194908
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to BRDT bromodomain 1 to 2 (N21to P380 amino acids) (unknown origin) using Alexa647-labeled BET-inhibitor as fluorescent probe by bromodomain TR-FRET binding assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bromodomain testis-specific protein (CHEMBL1795185) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.59 | 9.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4208129 | — | — | 1 | 9.16 |
| CHEMBL4217457 | — | — | 1 | 8.38 |
| CHEMBL4215988 | — | — | 1 | 8.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4208129 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL4217457 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL4215988 | — | Ki | = | 5.9 | nM | 8.23 |