Assay Detail
Functional
CHEMBL4195355
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Antiviral activity against HIV-1 LAI infected in human MT2 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.30 | 10.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4207145 | — | — | 1 | 10.64 |
| CHEMBL4214453 | — | — | 1 | 10.57 |
| CHEMBL4218875 | — | — | 1 | 9.05 |
| CHEMBL4211505 | — | — | 1 | 8.85 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 8.49 |
| CHEMBL4218164 | — | — | 1 | 8.05 |
| CHEMBL4210992 | — | — | 1 | 7.68 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 7.68 |
| CHEMBL4213229 | — | — | 1 | 7.54 |
| CHEMBL4205056 | — | — | 1 | 7.51 |
| CHEMBL4217920 | — | — | 1 | 6.89 |
| CHEMBL4214741 | — | — | 1 | 6.61 |
| CHEMBL4215950 | — | — | 1 | - |
| CHEMBL4206617 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4207145 | — | IC50 | = | 0.023 | nM | 10.64 |
| CHEMBL4214453 | — | IC50 | = | 0.027 | nM | 10.57 |
| CHEMBL4218875 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4211505 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1323 | DARUNAVIR | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4218164 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4210992 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL114 | SAQUINAVIR | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4213229 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4205056 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4217920 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4214741 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL4215950 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4206617 | — | IC50 | > | 1000.0 | nM | - |