Assay Detail
Functional
CHEMBL4195636
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Antiviral activity against Ebolavirus isolate Makona infected in human HeLa cells assessed as inhibition of viral infection pretreated for 2 hrs before viral infection and measured after 48 hrs by EboV GP immunostaining based method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Ebolavirus |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of Potent Ebola Virus Entry Inhibitors with Suitable Properties for in Vivo Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.18 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4203388 | — | — | 1 | 7.77 |
| CHEMBL4208258 | — | — | 1 | 7.28 |
| CHEMBL4205782 | — | — | 1 | 6.85 |
| CHEMBL2323039 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4203388 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4208258 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4205782 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2323039 | — | EC50 | = | 160.0 | nM | 6.80 |