Assay Detail
Functional
CHEMBL4195693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A375 cells harboring BRAF V600E mutant after 24 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of pyrazole derivatives containing acetamide bond as potential BRAFV600E inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.00 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4206547 | — | — | 1 | 6.02 |
| CHEMBL4209555 | — | — | 1 | 5.98 |
| CHEMBL4213568 | — | — | 1 | 5.56 |
| CHEMBL4210074 | — | — | 1 | 5.51 |
| CHEMBL4211435 | — | — | 1 | 5.49 |
| CHEMBL4217956 | — | — | 1 | 5.46 |
| CHEMBL4208630 | — | — | 1 | 5.34 |
| CHEMBL4215335 | — | — | 1 | 5.25 |
| CHEMBL4210104 | — | — | 1 | 4.99 |
| CHEMBL4205709 | — | — | 1 | 4.97 |
| CHEMBL4205180 | — | — | 1 | 4.95 |
| CHEMBL4209989 | — | — | 1 | 4.79 |
| CHEMBL4215872 | — | — | 1 | 4.78 |
| CHEMBL4214559 | — | — | 1 | 4.75 |
| CHEMBL4218392 | — | — | 1 | 4.75 |
| CHEMBL4205738 | — | — | 1 | 4.73 |
| CHEMBL4210916 | — | — | 1 | 4.71 |
| CHEMBL4203663 | — | — | 1 | 4.70 |
| CHEMBL4217416 | — | — | 1 | 4.70 |
| CHEMBL4208969 | — | — | 1 | 4.63 |
| CHEMBL4204094 | — | — | 1 | 4.63 |
| CHEMBL4208019 | — | — | 1 | 4.62 |
| CHEMBL4203142 | — | — | 1 | 4.61 |
| CHEMBL4211407 | — | — | 1 | 4.57 |
| CHEMBL4213026 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4206547 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4209555 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4213568 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL4210074 | — | IC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL4211435 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL4217956 | — | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL4208630 | — | IC50 | = | 4570.0 | nM | 5.34 |
| CHEMBL4215335 | — | IC50 | = | 5670.0 | nM | 5.25 |
| CHEMBL4210104 | — | IC50 | = | 10360.0 | nM | 4.99 |
| CHEMBL4205709 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4205180 | — | IC50 | = | 11230.0 | nM | 4.95 |
| CHEMBL4209989 | — | IC50 | = | 16230.0 | nM | 4.79 |
| CHEMBL4215872 | — | IC50 | = | 16780.0 | nM | 4.78 |
| CHEMBL4214559 | — | IC50 | = | 17920.0 | nM | 4.75 |
| CHEMBL4218392 | — | IC50 | = | 17560.0 | nM | 4.75 |
| CHEMBL4205738 | — | IC50 | = | 18630.0 | nM | 4.73 |
| CHEMBL4210916 | — | IC50 | = | 19370.0 | nM | 4.71 |
| CHEMBL4203663 | — | IC50 | = | 19780.0 | nM | 4.70 |
| CHEMBL4217416 | — | IC50 | = | 19830.0 | nM | 4.70 |
| CHEMBL4208969 | — | IC50 | = | 23680.0 | nM | 4.63 |
| CHEMBL4204094 | — | IC50 | = | 23340.0 | nM | 4.63 |
| CHEMBL4208019 | — | IC50 | = | 24230.0 | nM | 4.62 |
| CHEMBL4203142 | — | IC50 | = | 24530.0 | nM | 4.61 |
| CHEMBL4211407 | — | IC50 | = | 27160.0 | nM | 4.57 |
| CHEMBL4213026 | — | IC50 | = | 28890.0 | nM | 4.54 |