Assay Detail
Binding
CHEMBL4195748
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs by ADP-MR121 633 tracer based fluorescence polarization assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 14 (CHEMBL5888) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 9.02 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4205698 | — | — | 1 | 10.30 |
| CHEMBL4216289 | — | — | 1 | 10.15 |
| CHEMBL4215425 | — | — | 1 | 10.15 |
| CHEMBL4211046 | — | — | 1 | 10.10 |
| CHEMBL4204233 | — | — | 1 | 9.89 |
| CHEMBL4211551 | — | — | 1 | 9.77 |
| CHEMBL4217407 | — | — | 1 | 9.74 |
| CHEMBL4209095 | — | — | 1 | 9.64 |
| CHEMBL4212052 | — | — | 1 | 9.64 |
| CHEMBL4211840 | — | — | 1 | 9.64 |
| CHEMBL4208337 | — | — | 1 | 9.57 |
| CHEMBL4211560 | — | — | 1 | 9.38 |
| CHEMBL4214032 | — | — | 1 | 9.23 |
| CHEMBL4216004 | — | — | 1 | 9.07 |
| CHEMBL4217923 | — | — | 1 | 8.89 |
| CHEMBL4210461 | — | — | 1 | 8.70 |
| CHEMBL4205172 | — | — | 1 | 8.33 |
| CHEMBL4210066 | — | — | 1 | 8.23 |
| CHEMBL4203779 | — | — | 1 | 8.03 |
| CHEMBL4215454 | — | — | 1 | 7.80 |
| CHEMBL4203279 | — | — | 1 | 7.55 |
| CHEMBL4212983 | — | — | 1 | 7.17 |
| CHEMBL4206671 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4205698 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL4216289 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL4215425 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL4211046 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL4204233 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL4211551 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL4217407 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL4209095 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL4212052 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL4211840 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL4208337 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL4211560 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL4214032 | — | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL4216004 | — | Ki | = | 0.86 | nM | 9.07 |
| CHEMBL4217923 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL4210461 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4205172 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL4210066 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL4203779 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL4215454 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4203279 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL4212983 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL4206671 | — | Ki | = | 350.0 | nM | 6.46 |