Assay Detail
Binding
CHEMBL4195901
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 mins by ADP-Glo assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 6.93 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4205416 | — | — | 1 | 8.70 |
| CHEMBL4211696 | — | — | 1 | 8.40 |
| CHEMBL4215340 | — | — | 1 | 8.40 |
| CHEMBL4203566 | — | — | 1 | 8.15 |
| CHEMBL4215244 | — | — | 1 | 8.15 |
| CHEMBL2397317 | — | — | 1 | 8.10 |
| CHEMBL4209793 | — | — | 1 | 8.10 |
| CHEMBL4203041 | — | — | 1 | 8.10 |
| CHEMBL4207851 | — | — | 1 | 8.05 |
| CHEMBL1652677 | — | — | 1 | 8.00 |
| CHEMBL4211181 | — | — | 1 | 7.96 |
| CHEMBL4210308 | — | — | 1 | 7.96 |
| CHEMBL4204100 | — | — | 1 | 7.75 |
| CHEMBL4206816 | — | — | 1 | 7.72 |
| CHEMBL4207928 | — | — | 1 | 7.70 |
| CHEMBL4215615 | — | — | 1 | 7.38 |
| CHEMBL4217096 | — | — | 1 | 7.29 |
| CHEMBL4209824 | — | — | 1 | 6.94 |
| CHEMBL4205444 | — | — | 1 | 6.84 |
| CHEMBL4216301 | — | — | 1 | 6.76 |
| CHEMBL4210718 | — | — | 1 | 6.67 |
| CHEMBL4213363 | — | — | 1 | 6.56 |
| CHEMBL4210332 | — | — | 1 | 6.51 |
| CHEMBL4203671 | — | — | 1 | 6.50 |
| CHEMBL4202963 | — | — | 1 | 6.38 |
| CHEMBL4206897 | — | — | 1 | 6.29 |
| CHEMBL4214728 | — | — | 1 | 6.26 |
| CHEMBL4202542 | — | — | 1 | 6.21 |
| CHEMBL4205943 | — | — | 1 | 6.02 |
| CHEMBL4212822 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4205416 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4211696 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4215340 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4203566 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4215244 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2397317 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4209793 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4203041 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4207851 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1652677 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4210308 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4211181 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4204100 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4206816 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4207928 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4215615 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4217096 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4209824 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL4205444 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL4216301 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL4210718 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL4213363 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL4210332 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL4203671 | — | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL4202963 | — | IC50 | = | 414.0 | nM | 6.38 |
| CHEMBL4206897 | — | IC50 | = | 517.0 | nM | 6.29 |
| CHEMBL4214728 | — | IC50 | = | 548.0 | nM | 6.26 |
| CHEMBL4202542 | — | IC50 | = | 611.0 | nM | 6.21 |
| CHEMBL4205943 | — | IC50 | = | 946.0 | nM | 6.02 |
| CHEMBL4212822 | — | IC50 | = | 981.0 | nM | 6.01 |
| CHEMBL4215775 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4208440 | — | IC50 | = | 1412.0 | nM | 5.85 |
| CHEMBL4204633 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4214225 | — | IC50 | = | 1946.0 | nM | 5.71 |
| CHEMBL4217771 | — | IC50 | = | 2577.0 | nM | 5.59 |
| CHEMBL4208976 | — | IC50 | = | 2583.0 | nM | 5.59 |
| CHEMBL4218639 | — | IC50 | = | 3387.0 | nM | 5.47 |
| CHEMBL4215673 | — | IC50 | = | 5743.0 | nM | 5.24 |
| CHEMBL4213240 | — | IC50 | = | 6138.0 | nM | 5.21 |
| CHEMBL4212121 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL4218178 | — | IC50 | > | 10000.0 | nM | - |