Compound Detail
CHEMBL4206816
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Basic Information
| ChEMBL ID | CHEMBL4206816 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UWTRKIJAGTTXNM-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
2
PK Parameters
9
Publications
0
Known Names
Molecular Properties
446.5
MW (Da)
3.39
ALogP
8
HBA
2
HBD
113.2
PSA (Ų)
0.50
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4-kinase beta CHEMBL3268 | IC50 | 8.3 | 8.01 | 5.0 | 2 |
| Cytochrome P450 3A4 CHEMBL340 | IC50 | 6.05 | 6.05 | 900.0 | 1 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 5.7 | 5.7 | 2000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 32.0 | mL.min-1.g-1 | Homo sapiens |
| CL | 72.0 | mL.min-1.g-1 | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4-kinase beta | IC50 | = | 5.0 | nM | 8.3 | Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treat... | 29952567 |
| Phosphatidylinositol 4-kinase beta | IC50 | = | 19.0 | nM | 7.72 | Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in ba... | 29952567 |
| Cytochrome P450 3A4 | IC50 | = | 900.0 | nM | 6.05 | Inhibition of CYP3A4 in human liver microsomes assessed as decrease in midazolam... | 29952567 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 2000.0 | nM | 5.7 | Inhibition of human ERG by cell based automated patch clamp method | 29952567 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29952567 | 10.1021/acs.jmedchem.8b00521 | Unchecked | 4 |
| 29952567 | 10.1021/acs.jmedchem.8b00521 | Phosphatidylinositol 4-kinase beta | 2 |
| 29952567 | 10.1021/acs.jmedchem.8b00521 | ADMET | 2 |
| 29952567 | 10.1021/acs.jmedchem.8b00521 | No relevant target | 2 |
| 29952567 | 10.1021/acs.jmedchem.8b00521 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 29952567 | 10.1021/acs.jmedchem.8b00521 | Cytochrome P450 3A4 | 1 |
| 29952567 | 10.1021/acs.jmedchem.8b00521 | Phosphatidylinositol 4-kinase type 2-alpha | 1 |
| 29952567 | 10.1021/acs.jmedchem.8b00521 | Phosphatidylinositol 4-kinase type 2-beta | 1 |
| 29952567 | 10.1021/acs.jmedchem.8b00521 | Phosphatidylinositol 4-kinase alpha | 1 |
Data from ChEMBL 36 via Core Engine