Assay Detail
ADMET
CHEMBL4195907
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Inhibition of CYP3A4 in human liver microsomes assessed as decrease in midazolam 1-hydroxylation by LC-MS/MS analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.93 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4206816 | — | — | 1 | 6.05 |
| CHEMBL4205416 | — | — | 1 | 5.80 |
| CHEMBL4217096 | — | — | 1 | - |
| CHEMBL4209793 | — | — | 1 | - |
| CHEMBL1652677 | — | — | 1 | - |
| CHEMBL4210308 | — | — | 1 | - |
| CHEMBL4215340 | — | — | 1 | - |
| CHEMBL4203041 | — | — | 1 | - |
| CHEMBL4207928 | — | — | 1 | - |
| CHEMBL4215244 | — | — | 1 | - |
| CHEMBL4203566 | — | — | 1 | - |
| CHEMBL4204633 | — | — | 1 | - |
| CHEMBL4204100 | — | — | 1 | - |
| CHEMBL4208976 | — | — | 1 | - |
| CHEMBL4208440 | — | — | 1 | - |
| CHEMBL4213363 | — | — | 1 | - |
| CHEMBL4212822 | — | — | 1 | - |
| CHEMBL4217771 | — | — | 1 | - |
| CHEMBL4211181 | — | — | 1 | - |
| CHEMBL4203671 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4206816 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4205416 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4217096 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4209793 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1652677 | — | IC50 | - | — | - | |
| CHEMBL4210308 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4215340 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4203041 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4207928 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4215244 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4203566 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4204633 | — | IC50 | - | — | - | |
| CHEMBL4204100 | — | IC50 | - | — | - | |
| CHEMBL4208976 | — | IC50 | - | — | - | |
| CHEMBL4208440 | — | IC50 | - | — | - | |
| CHEMBL4213363 | — | IC50 | - | — | - | |
| CHEMBL4212822 | — | IC50 | - | — | - | |
| CHEMBL4217771 | — | IC50 | - | — | - | |
| CHEMBL4211181 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4203671 | — | IC50 | - | — | - |