Assay Detail
Binding
CHEMBL4196310
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Inhibition of human thrombin using H-D-phenylalanyl-L-pipecolyl-L-arginine-p-nitroaniline dihydrochloride as substrate after 60 mins
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The selectivity and bioavailability improvement of novel oral anticoagulants: An overview.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.41 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75084 | — | — | 1 | 6.80 |
| CHEMBL125781 | — | — | 1 | 6.02 |
| CHEMBL133623 | — | — | 1 | 5.12 |
| CHEMBL77490 | — | — | 1 | 5.10 |
| CHEMBL4202662 | — | — | 1 | 4.00 |
| CHEMBL77076 | — | — | 1 | - |
| CHEMBL4215577 | — | — | 1 | - |
| CHEMBL142205 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75084 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL125781 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL133623 | — | IC50 | = | 7630.0 | nM | 5.12 |
| CHEMBL77490 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4202662 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL77076 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4215577 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL142205 | — | IC50 | > | 30000.0 | nM | - |