Assay Detail
Binding
CHEMBL4196336
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human thrombin using tosyl-glycyl-prolyl-arginine-4-nitranilide acetate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometric method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The selectivity and bioavailability improvement of novel oral anticoagulants: An overview.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.53 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48635 | — | — | 1 | 8.27 |
| CHEMBL48361 | DABIGATRAN | 3.0 | 1 | 8.03 |
| CHEMBL298500 | — | — | 1 | 7.96 |
| CHEMBL417360 | — | — | 1 | 7.50 |
| CHEMBL51528 | — | — | 1 | 7.24 |
| CHEMBL23430 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48635 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL48361 | DABIGATRAN | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL298500 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL417360 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL51528 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL23430 | — | IC50 | = | 690.0 | nM | 6.16 |