Assay Detail
Functional
CHEMBL4196481
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SEM cells after 72 hrs by CelTiter-Glo assay
72
Total Activities
72
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel vitexin-inspired scaffold against leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 72 | 5.27 | 6.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 6.69 |
| CHEMBL3545110 | RIBOCICLIB | 4.0 | 1 | 6.34 |
| CHEMBL4207638 | — | — | 1 | 6.32 |
| CHEMBL4216565 | — | — | 1 | 5.89 |
| CHEMBL4212807 | — | — | 1 | 5.72 |
| CHEMBL4210247 | — | — | 1 | 5.41 |
| CHEMBL4217234 | — | — | 1 | 5.26 |
| CHEMBL4218283 | — | — | 1 | 5.24 |
| CHEMBL4211996 | — | — | 1 | 4.97 |
| CHEMBL4209544 | — | — | 1 | 4.92 |
| CHEMBL4206016 | — | — | 1 | 4.65 |
| CHEMBL4213949 | — | — | 1 | 4.58 |
| CHEMBL139216 | — | — | 1 | 4.54 |
| CHEMBL4218784 | — | — | 1 | 4.33 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 4.23 |
| CHEMBL4212347 | — | — | 1 | - |
| CHEMBL4206533 | — | — | 1 | - |
| CHEMBL4213852 | — | — | 1 | - |
| CHEMBL4207513 | — | — | 1 | - |
| CHEMBL4209460 | — | — | 1 | - |
| CHEMBL4214363 | — | — | 1 | - |
| CHEMBL4212977 | — | — | 1 | - |
| CHEMBL4208071 | — | — | 1 | - |
| CHEMBL4216450 | — | — | 1 | - |
| CHEMBL4211482 | — | — | 1 | - |
| CHEMBL4204255 | — | — | 1 | - |
| CHEMBL4215920 | — | — | 1 | - |
| CHEMBL487417 | VITEXIN | — | 1 | - |
| CHEMBL4211234 | — | — | 1 | - |
| CHEMBL4218261 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | EC50 | = | 204.3 | nM | 6.69 |
| CHEMBL3545110 | RIBOCICLIB | EC50 | = | 460.5 | nM | 6.34 |
| CHEMBL4207638 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4216565 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4212807 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4210247 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4217234 | — | EC50 | = | 5515.8 | nM | 5.26 |
| CHEMBL4218283 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4211996 | — | EC50 | = | 10750.0 | nM | 4.97 |
| CHEMBL4209544 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4206016 | — | EC50 | = | 22543.2 | nM | 4.65 |
| CHEMBL4213949 | — | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL139216 | — | EC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4218784 | — | EC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL44 | GENISTEIN | EC50 | = | 59338.0 | nM | 4.23 |
| CHEMBL4205078 | — | EC50 | > | 86206.9 | nM | - |
| CHEMBL4208959 | — | EC50 | > | 34482.8 | nM | - |
| CHEMBL4215320 | — | EC50 | > | 6350.6 | nM | - |
| CHEMBL4210374 | — | EC50 | > | 8082.3 | nM | - |
| CHEMBL4204580 | — | EC50 | > | 11545.5 | nM | - |
| CHEMBL4209449 | — | EC50 | > | 13852.8 | nM | - |
| CHEMBL4208917 | — | EC50 | > | 25284.5 | nM | - |
| CHEMBL4216767 | — | EC50 | > | 24137.9 | nM | - |
| CHEMBL4213842 | — | EC50 | > | 19543.1 | nM | - |
| CHEMBL4217304 | — | EC50 | > | 13277.1 | nM | - |
| CHEMBL4204880 | — | EC50 | - | — | - | |
| CHEMBL8260 | BAICALEIN | EC50 | - | — | - | |
| CHEMBL4206614 | — | EC50 | > | 31168.8 | nM | - |
| CHEMBL4218874 | — | EC50 | > | 17316.0 | nM | - |
| CHEMBL4214451 | — | EC50 | > | 27705.6 | nM | - |
| CHEMBL4211339 | — | EC50 | - | — | - | |
| CHEMBL4205519 | — | EC50 | - | — | - | |
| CHEMBL4212977 | — | EC50 | > | 16379.3 | nM | - |
| CHEMBL4218261 | — | EC50 | > | 6350.6 | nM | - |
| CHEMBL4211234 | — | EC50 | > | 43290.0 | nM | - |
| CHEMBL487417 | VITEXIN | EC50 | > | 43290.0 | nM | - |
| CHEMBL4215920 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4204255 | — | EC50 | > | 32181.0 | nM | - |
| CHEMBL4211482 | — | EC50 | > | 58620.7 | nM | - |
| CHEMBL4216450 | — | EC50 | > | 54025.9 | nM | - |
| CHEMBL4208071 | — | EC50 | > | 77008.6 | nM | - |
| CHEMBL4203612 | — | EC50 | > | 9813.9 | nM | - |
| CHEMBL4214363 | — | EC50 | - | — | - | |
| CHEMBL4209460 | — | EC50 | - | — | - | |
| CHEMBL4207513 | — | EC50 | > | 16160.2 | nM | - |
| CHEMBL4213852 | — | EC50 | > | 20203.5 | nM | - |
| CHEMBL4206533 | — | EC50 | > | 6350.6 | nM | - |
| CHEMBL4212347 | — | EC50 | > | 43290.0 | nM | - |
| CHEMBL4208488 | — | EC50 | > | 12121.2 | nM | - |
| CHEMBL4210902 | — | EC50 | > | 6350.6 | nM | - |