Assay Detail
Binding
CHEMBL4196838
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Inhibition of PGPH activity of human 26S proteasome using Z-LLE-MCA as substrate measured for 1 hr by fluorescence assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Ridaifen-F conjugated with cell-penetrating peptides inhibits intracellular proteasome activities and induces drug-resistant cell death.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.41 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.72 |
| CHEMBL4209883 | — | — | 1 | 4.77 |
| CHEMBL4210397 | — | — | 1 | 4.66 |
| CHEMBL4206039 | — | — | 1 | 4.48 |
| CHEMBL4212401 | — | — | 1 | - |
| CHEMBL4217338 | — | — | 1 | - |
| CHEMBL4212383 | — | — | 1 | - |
| CHEMBL4212914 | — | — | 1 | - |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | - |
| CHEMBL374308 | LACTACYSTIN | — | 1 | - |
| CHEMBL3099618 | — | — | 1 | - |
| CHEMBL4215864 | — | — | 1 | - |
| CHEMBL4218282 | — | — | 1 | - |
| CHEMBL4213348 | — | — | 1 | - |
| CHEMBL4217753 | — | — | 1 | - |
| CHEMBL4205518 | — | — | 1 | - |
| CHEMBL4204198 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4209883 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4210397 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4206039 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL4212401 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4217338 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4212383 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4212914 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL159 | VINBLASTINE | IC50 | > | 40000.0 | nM | - |
| CHEMBL374308 | LACTACYSTIN | IC50 | > | 40000.0 | nM | - |
| CHEMBL3099618 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4215864 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4218282 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4213348 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4217753 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4205518 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4204198 | — | IC50 | > | 40000.0 | nM | - |