Assay Detail
Binding
CHEMBL4196844
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Inhibition of trypsin-like activity of 26S proteasome in human KMS11 cells using Boc-LRR-MCA as substrate after 24 to 48 hrs by luminescence-based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Ridaifen-F conjugated with cell-penetrating peptides inhibits intracellular proteasome activities and induces drug-resistant cell death.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.25 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4217338 | — | — | 1 | 5.39 |
| CHEMBL4212401 | — | — | 1 | 5.10 |
| CHEMBL3099618 | — | — | 1 | - |
| CHEMBL4212383 | — | — | 1 | - |
| CHEMBL4212914 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4217338 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4212401 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3099618 | — | IC50 | - | — | - | |
| CHEMBL4212383 | — | IC50 | - | — | - | |
| CHEMBL4212914 | — | IC50 | - | — | - |