Assay Detail
Binding
CHEMBL4197054
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CDK6/Cyclin-D3
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis and biological evaluation of tetrahydronaphthyridine derivatives as bioavailable CDK4/6 inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.40 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4203179 | — | — | 1 | 8.80 |
| CHEMBL3301610 | ABEMACICLIB | 4.0 | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4203179 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3301610 | ABEMACICLIB | IC50 | = | 10.0 | nM | 8.00 |