Assay Detail
Functional
CHEMBL4197329
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Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 48 hrs by MTS assay
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 5.71 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4202862 | — | — | 1 | 6.80 |
| CHEMBL4208987 | — | — | 1 | 6.77 |
| CHEMBL4214392 | — | — | 1 | 6.72 |
| CHEMBL4217329 | — | — | 1 | 6.58 |
| CHEMBL4207887 | — | — | 1 | 6.52 |
| CHEMBL4211443 | — | — | 1 | 6.50 |
| CHEMBL4205081 | — | — | 1 | 6.42 |
| CHEMBL4210193 | — | — | 1 | 6.40 |
| CHEMBL4207736 | — | — | 1 | 6.25 |
| CHEMBL4206146 | — | — | 1 | 6.21 |
| CHEMBL4211559 | — | — | 1 | 6.21 |
| CHEMBL4210628 | — | — | 1 | 6.11 |
| CHEMBL4212997 | — | — | 1 | 6.06 |
| CHEMBL4210467 | — | — | 1 | 5.92 |
| CHEMBL4204467 | — | — | 1 | 5.83 |
| CHEMBL4211852 | — | — | 1 | 5.81 |
| CHEMBL4214959 | — | — | 1 | 5.71 |
| CHEMBL4216538 | — | — | 1 | 5.65 |
| CHEMBL4203389 | — | — | 1 | 5.60 |
| CHEMBL4208800 | — | — | 1 | 5.60 |
| CHEMBL4206558 | — | — | 1 | 5.60 |
| CHEMBL4218733 | — | — | 1 | 5.56 |
| CHEMBL4210429 | — | — | 1 | 5.55 |
| CHEMBL4215055 | — | — | 1 | 5.52 |
| CHEMBL4206450 | — | — | 1 | 5.52 |
| CHEMBL4215881 | — | — | 1 | 5.51 |
| CHEMBL4214770 | — | — | 1 | 5.36 |
| CHEMBL4203645 | — | — | 1 | 5.35 |
| CHEMBL4210923 | — | — | 1 | 5.35 |
| CHEMBL1208572 | SALINOMYCIN | 2.0 | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4202862 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4208987 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4214392 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4217329 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4207887 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4211443 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4205081 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4210193 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4207736 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4206146 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4211559 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4210628 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4212997 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4210467 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4204467 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL4211852 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL4214959 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL4216538 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL4203389 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL4208800 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL4206558 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL4218733 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL4210429 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL4215055 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL4206450 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL4215881 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL4214770 | — | IC50 | = | 4360.0 | nM | 5.36 |
| CHEMBL4203645 | — | IC50 | = | 4470.0 | nM | 5.35 |
| CHEMBL4210923 | — | IC50 | = | 4480.0 | nM | 5.35 |
| CHEMBL1208572 | SALINOMYCIN | IC50 | = | 4490.0 | nM | 5.35 |
| CHEMBL4211153 | — | IC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL4211587 | — | IC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL4216133 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL4216954 | — | IC50 | = | 5380.0 | nM | 5.27 |
| CHEMBL4212899 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4202415 | — | IC50 | = | 6560.0 | nM | 5.18 |
| CHEMBL4216173 | — | IC50 | = | 7020.0 | nM | 5.15 |
| CHEMBL4210001 | — | IC50 | = | 8690.0 | nM | 5.06 |
| CHEMBL4214202 | — | IC50 | = | 9080.0 | nM | 5.04 |
| CHEMBL4204180 | — | IC50 | = | 10770.0 | nM | 4.97 |
| CHEMBL4208836 | — | IC50 | = | 13490.0 | nM | 4.87 |
| CHEMBL4207012 | — | IC50 | = | 14920.0 | nM | 4.83 |
| CHEMBL4213192 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4217845 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4208264 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4206270 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4203919 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4209051 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4214915 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4202729 | — | IC50 | > | 20000.0 | nM | - |