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Assay Detail

CHEMBL4197333

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human BEAS2B cells assessed as cell growth inhibition after 48 hrs by MTS assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type BEAS-2B
Confidence 1 — Organism
Curated By Intermediate

Target

BEAS-2B (CHEMBL4296403)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
Li Y, Shi Q, Shao J, Yuan Y, Yang Z, Chen S, Zhou X, Wen S, Jiang ZX.
Eur J Med Chem (2018) 148 : 279 -290
PubMed 29466777 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.05 5.34

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4206146 1 5.34
CHEMBL4214392 1 5.25
CHEMBL4202862 1 5.20
CHEMBL4203389 1 5.16
CHEMBL4207736 1 5.14
CHEMBL4218733 1 5.10
CHEMBL4211852 1 5.08
CHEMBL4215055 1 5.08
CHEMBL4211559 1 5.07
CHEMBL4208987 1 5.03
CHEMBL4207887 1 4.99
CHEMBL4210923 1 4.97
CHEMBL4214959 1 4.96
CHEMBL4211153 1 4.91
CHEMBL4214770 1 4.88
CHEMBL1208572 SALINOMYCIN 2.0 1 4.88
CHEMBL4205081 1 4.74

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4206146 IC50 = 4580.0 nM 5.34
CHEMBL4214392 IC50 = 5580.0 nM 5.25
CHEMBL4202862 IC50 = 6270.0 nM 5.20
CHEMBL4203389 IC50 = 6970.0 nM 5.16
CHEMBL4207736 IC50 = 7290.0 nM 5.14
CHEMBL4218733 IC50 = 8020.0 nM 5.10
CHEMBL4211852 IC50 = 8260.0 nM 5.08
CHEMBL4215055 IC50 = 8380.0 nM 5.08
CHEMBL4211559 IC50 = 8520.0 nM 5.07
CHEMBL4208987 IC50 = 9250.0 nM 5.03
CHEMBL4207887 IC50 = 10320.0 nM 4.99
CHEMBL4210923 IC50 = 10620.0 nM 4.97
CHEMBL4214959 IC50 = 11090.0 nM 4.96
CHEMBL4211153 IC50 = 12350.0 nM 4.91
CHEMBL4214770 IC50 = 13060.0 nM 4.88
CHEMBL1208572 SALINOMYCIN IC50 = 13070.0 nM 4.88
CHEMBL4205081 IC50 = 18260.0 nM 4.74