Assay Detail
Functional
CHEMBL4197342
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Cytotoxicity against doxycycline inducible T-Rex/K-Ras G12V HEK293 cells assessed as cell growth inhibition after 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.41 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4214392 | — | — | 1 | 8.17 |
| CHEMBL4206146 | — | — | 1 | 7.76 |
| CHEMBL4202862 | — | — | 1 | 7.45 |
| CHEMBL4207736 | — | — | 1 | 7.30 |
| CHEMBL4208987 | — | — | 1 | 7.29 |
| CHEMBL1208572 | SALINOMYCIN | 2.0 | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4214392 | — | IC50 | = | 6.83 | nM | 8.17 |
| CHEMBL4206146 | — | IC50 | = | 17.2 | nM | 7.76 |
| CHEMBL4202862 | — | IC50 | = | 35.46 | nM | 7.45 |
| CHEMBL4207736 | — | IC50 | = | 50.44 | nM | 7.30 |
| CHEMBL4208987 | — | IC50 | = | 51.48 | nM | 7.29 |
| CHEMBL1208572 | SALINOMYCIN | IC50 | = | 329.5 | nM | 6.48 |