Assay Detail
Functional
CHEMBL4197819
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 pseudotyped MARV infected in HEK293T cells assessed as reduction in virus induced cytopathic effect by luciferase reporter gene assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Marburgvirus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery and evolution of aloperine derivatives as novel anti-filovirus agents through targeting entry stage.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 4.80 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4212624 | — | — | 1 | 6.05 |
| CHEMBL4211932 | — | — | 1 | 5.19 |
| CHEMBL4207565 | — | — | 1 | 5.15 |
| CHEMBL4207052 | — | — | 1 | 5.07 |
| CHEMBL4205951 | — | — | 1 | 5.01 |
| CHEMBL3329704 | — | — | 1 | 4.99 |
| CHEMBL4207706 | — | — | 1 | 4.98 |
| CHEMBL4215857 | — | — | 1 | 4.92 |
| CHEMBL4203365 | — | — | 1 | 4.82 |
| CHEMBL4202702 | — | — | 1 | 4.75 |
| CHEMBL4215553 | — | — | 1 | 4.73 |
| CHEMBL4216378 | — | — | 1 | 4.67 |
| CHEMBL4204187 | — | — | 1 | 4.66 |
| CHEMBL4212614 | — | — | 1 | 4.57 |
| CHEMBL4211416 | — | — | 1 | 4.45 |
| CHEMBL4212060 | — | — | 1 | 4.21 |
| CHEMBL4217037 | — | — | 1 | 4.15 |
| CHEMBL4206112 | — | — | 1 | 4.09 |
| CHEMBL4211002 | — | — | 1 | - |
| CHEMBL4203879 | — | — | 1 | - |
| CHEMBL4203360 | — | — | 1 | - |
| CHEMBL4208233 | — | — | 1 | - |
| CHEMBL4206756 | — | — | 1 | - |
| CHEMBL4211634 | — | — | 1 | - |
| CHEMBL4217574 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4212624 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4211932 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4207565 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4207052 | — | EC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4205951 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL3329704 | — | EC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL4207706 | — | EC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4215857 | — | EC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL4203365 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4202702 | — | EC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL4215553 | — | EC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL4216378 | — | EC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL4204187 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4212614 | — | EC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL4211416 | — | EC50 | = | 35300.0 | nM | 4.45 |
| CHEMBL4212060 | — | EC50 | = | 62400.0 | nM | 4.21 |
| CHEMBL4217037 | — | EC50 | = | 70700.0 | nM | 4.15 |
| CHEMBL4206112 | — | EC50 | = | 80800.0 | nM | 4.09 |
| CHEMBL4211002 | — | EC50 | = | 111500.0 | nM | - |
| CHEMBL4203879 | — | EC50 | - | — | - | |
| CHEMBL4203360 | — | EC50 | - | — | - | |
| CHEMBL4208233 | — | EC50 | - | — | - | |
| CHEMBL4206756 | — | EC50 | - | — | - | |
| CHEMBL4211634 | — | EC50 | - | — | - | |
| CHEMBL4217574 | — | EC50 | - | — | - |