Assay Detail
Functional
CHEMBL4197897
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins followed by LPS stimulation and measured after 24 hrs by Griess assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BV-2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of compounds with a new scaffold as anti-neuroinflammatory agents for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 4.85 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4215895 | — | — | 1 | 6.00 |
| CHEMBL4208039 | — | — | 1 | 5.52 |
| CHEMBL4204115 | — | — | 1 | 5.19 |
| CHEMBL4204648 | — | — | 1 | 5.14 |
| CHEMBL4215996 | — | — | 1 | 5.10 |
| CHEMBL4215361 | — | — | 1 | 5.10 |
| CHEMBL4208458 | — | — | 1 | 5.09 |
| CHEMBL4211038 | — | — | 1 | 5.02 |
| CHEMBL4211871 | — | — | 1 | 5.00 |
| CHEMBL4213922 | — | — | 1 | 5.00 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 4.96 |
| CHEMBL4216315 | — | — | 1 | 4.96 |
| CHEMBL4212508 | — | — | 1 | 4.90 |
| CHEMBL4209009 | — | — | 1 | 4.83 |
| CHEMBL4209933 | — | — | 1 | 4.81 |
| CHEMBL4203772 | — | — | 1 | 4.75 |
| CHEMBL4214848 | — | — | 1 | 4.70 |
| CHEMBL4206086 | — | — | 1 | 4.65 |
| CHEMBL4213384 | — | — | 1 | 4.64 |
| CHEMBL4216842 | — | — | 1 | 4.60 |
| CHEMBL4210442 | — | — | 1 | 4.57 |
| CHEMBL4217804 | — | — | 1 | 4.50 |
| CHEMBL4205571 | — | — | 1 | 4.43 |
| CHEMBL4213401 | — | — | 1 | 4.40 |
| CHEMBL4208994 | — | — | 1 | 4.37 |
| CHEMBL4203687 | — | — | 1 | 4.33 |
| CHEMBL4214788 | — | — | 1 | 4.32 |
| CHEMBL4207601 | — | — | 1 | - |
| CHEMBL4203166 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4215895 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4208039 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4204115 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4204648 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4215996 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4215361 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4208458 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4211038 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4211871 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL4213922 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL165 | RESVERATROL | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL4216315 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4212508 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL4209009 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL4209933 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL4203772 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL4214848 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL4206086 | — | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL4213384 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL4216842 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL4210442 | — | IC50 | = | 26900.0 | nM | 4.57 |
| CHEMBL4217804 | — | IC50 | = | 31700.0 | nM | 4.50 |
| CHEMBL4205571 | — | IC50 | = | 37200.0 | nM | 4.43 |
| CHEMBL4213401 | — | IC50 | = | 39800.0 | nM | 4.40 |
| CHEMBL4208994 | — | IC50 | = | 42600.0 | nM | 4.37 |
| CHEMBL4203687 | — | IC50 | = | 46800.0 | nM | 4.33 |
| CHEMBL4214788 | — | IC50 | = | 48100.0 | nM | 4.32 |
| CHEMBL4207601 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4203166 | — | IC50 | > | 50000.0 | nM | - |