Assay Detail
Functional
CHEMBL4197898
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BV-2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of compounds with a new scaffold as anti-neuroinflammatory agents for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 4.76 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4215895 | — | — | 1 | 5.58 |
| CHEMBL4215361 | — | — | 1 | 5.23 |
| CHEMBL4208039 | — | — | 1 | 5.18 |
| CHEMBL4204115 | — | — | 1 | 5.16 |
| CHEMBL4216315 | — | — | 1 | 5.03 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 5.02 |
| CHEMBL4204648 | — | — | 1 | 4.96 |
| CHEMBL4208458 | — | — | 1 | 4.82 |
| CHEMBL4212508 | — | — | 1 | 4.79 |
| CHEMBL4211038 | — | — | 1 | 4.77 |
| CHEMBL4213922 | — | — | 1 | 4.75 |
| CHEMBL4216842 | — | — | 1 | 4.75 |
| CHEMBL4209933 | — | — | 1 | 4.70 |
| CHEMBL4209009 | — | — | 1 | 4.67 |
| CHEMBL4215996 | — | — | 1 | 4.67 |
| CHEMBL4211871 | — | — | 1 | 4.62 |
| CHEMBL4214848 | — | — | 1 | 4.60 |
| CHEMBL4206086 | — | — | 1 | 4.58 |
| CHEMBL4205571 | — | — | 1 | 4.57 |
| CHEMBL4217804 | — | — | 1 | 4.46 |
| CHEMBL4203772 | — | — | 1 | 4.45 |
| CHEMBL4214788 | — | — | 1 | 4.44 |
| CHEMBL4203166 | — | — | 1 | 4.43 |
| CHEMBL4213384 | — | — | 1 | 4.38 |
| CHEMBL4210442 | — | — | 1 | 4.37 |
| CHEMBL4213401 | — | — | 1 | - |
| CHEMBL4203687 | — | — | 1 | - |
| CHEMBL4207601 | — | — | 1 | - |
| CHEMBL4208994 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4215895 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4215361 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4208039 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4204115 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4216315 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL165 | RESVERATROL | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4204648 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL4208458 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL4212508 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL4211038 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL4213922 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL4216842 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL4209933 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL4209009 | — | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL4215996 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL4211871 | — | IC50 | = | 23700.0 | nM | 4.62 |
| CHEMBL4214848 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL4206086 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL4205571 | — | IC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL4217804 | — | IC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL4203772 | — | IC50 | = | 35400.0 | nM | 4.45 |
| CHEMBL4214788 | — | IC50 | = | 36400.0 | nM | 4.44 |
| CHEMBL4203166 | — | IC50 | = | 37500.0 | nM | 4.43 |
| CHEMBL4213384 | — | IC50 | = | 41300.0 | nM | 4.38 |
| CHEMBL4210442 | — | IC50 | = | 43100.0 | nM | 4.37 |
| CHEMBL4213401 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4203687 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4207601 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4208994 | — | IC50 | > | 50000.0 | nM | - |