Assay Detail
Functional
CHEMBL4197986
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 infected in human PBMC measured at 7 to 10 days post infection by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
The chemical diversity and structure-based evolution of non-peptide CXCR4 antagonists with diverse therapeutic potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.86 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1242211 | — | — | 1 | 9.52 |
| CHEMBL4214553 | — | — | 1 | 8.70 |
| CHEMBL4211083 | — | — | 1 | 8.70 |
| CHEMBL4206197 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1242211 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4214553 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4211083 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4206197 | — | EC50 | = | 3.0 | nM | 8.52 |