Assay Detail
Functional
CHEMBL4198055
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Cytotoxicity against human SW620/AD300 cells assessed as reduction in cell viability after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW620/AD300 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.47 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4205613 | — | — | 1 | 7.57 |
| CHEMBL4215928 | — | — | 1 | 7.52 |
| CHEMBL4202712 | — | — | 1 | 7.30 |
| CHEMBL4209981 | — | — | 1 | 7.22 |
| CHEMBL4204700 | — | — | 1 | 7.00 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.71 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 4.82 |
| CHEMBL4208369 | — | — | 1 | 4.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4205613 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4215928 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4202712 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4209981 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4204700 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 15240.0 | nM | 4.82 |
| CHEMBL4208369 | — | IC50 | = | 23370.0 | nM | 4.63 |