Assay Detail
Functional
CHEMBL4198685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HEL cells after 48 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of meta-sulfamoyl N-hydroxybenzamides as HDAC8 selective inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.82 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 7.00 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.82 |
| CHEMBL2170177 | — | — | 1 | 4.97 |
| CHEMBL4218377 | — | — | 1 | 4.48 |
| CHEMBL4206936 | — | — | 1 | - |
| CHEMBL4218674 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408513 | BELINOSTAT | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2170177 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL4218377 | — | IC50 | = | 32800.0 | nM | 4.48 |
| CHEMBL4206936 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4218674 | — | IC50 | > | 50000.0 | nM | - |