Assay Detail
Binding
CHEMBL4198693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured at 2 mins time interval by Ellman's method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.30 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292314 | — | — | 1 | 7.75 |
| CHEMBL4210729 | — | — | 1 | 7.38 |
| CHEMBL4213591 | — | — | 1 | 7.29 |
| CHEMBL4215217 | — | — | 1 | 7.13 |
| CHEMBL4215154 | — | — | 1 | 7.05 |
| CHEMBL4217346 | — | — | 1 | 7.03 |
| CHEMBL4203672 | — | — | 1 | 6.92 |
| CHEMBL4214668 | — | — | 1 | 6.89 |
| CHEMBL4217660 | — | — | 1 | 6.75 |
| CHEMBL4205374 | — | — | 1 | 6.73 |
| CHEMBL4206484 | — | — | 1 | 6.71 |
| CHEMBL4214900 | — | — | 1 | 6.71 |
| CHEMBL4202784 | — | — | 1 | 6.53 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.50 |
| CHEMBL4209755 | — | — | 1 | 6.31 |
| CHEMBL4204901 | — | — | 1 | 6.12 |
| CHEMBL4217617 | — | — | 1 | 5.82 |
| CHEMBL4217126 | — | — | 1 | 5.65 |
| CHEMBL4212151 | — | — | 1 | 5.58 |
| CHEMBL4204913 | — | — | 1 | 5.10 |
| CHEMBL4216601 | — | — | 1 | 5.02 |
| CHEMBL1256415 | — | — | 1 | 5.00 |
| CHEMBL4205910 | — | — | 1 | 5.00 |
| CHEMBL4210274 | — | — | 1 | 4.13 |
| CHEMBL608112 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292314 | — | IC50 | = | 17.6 | nM | 7.75 |
| CHEMBL4210729 | — | IC50 | = | 41.9 | nM | 7.38 |
| CHEMBL4213591 | — | IC50 | = | 51.7 | nM | 7.29 |
| CHEMBL4215217 | — | IC50 | = | 74.5 | nM | 7.13 |
| CHEMBL4215154 | — | IC50 | = | 89.6 | nM | 7.05 |
| CHEMBL4217346 | — | IC50 | = | 94.1 | nM | 7.03 |
| CHEMBL4203672 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4214668 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL4217660 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4205374 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL4206484 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL4214900 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL4202784 | — | IC50 | = | 293.0 | nM | 6.53 |
| CHEMBL95 | TACRINE | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4209755 | — | IC50 | = | 491.0 | nM | 6.31 |
| CHEMBL4204901 | — | IC50 | = | 768.0 | nM | 6.12 |
| CHEMBL4217617 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4217126 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL4212151 | — | IC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL4204913 | — | IC50 | = | 8020.0 | nM | 5.10 |
| CHEMBL4216601 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL1256415 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4205910 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4210274 | — | IC50 | = | 74300.0 | nM | 4.13 |
| CHEMBL608112 | — | IC50 | > | 1000000.0 | nM | - |