Assay Detail
Functional
CHEMBL4198708
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Middle East respiratory syndrome-related coronavirus infected in African green monkey Vero81 cells assessed as reduction in viral titer after 48 hrs
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Middle East respiratory syndrome-related coronavirus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Middle East respiratory syndrome-related coronavirus (CHEMBL4296578) ↗| Type | ORGANISM |
| Organism | Middle East respiratory syndrome-related coronavirus |
Publication
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.20 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4208240 | — | — | 1 | 6.30 |
| CHEMBL4203883 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4208240 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4203883 | — | EC50 | = | 800.0 | nM | 6.10 |