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Assay Detail

CHEMBL4199520

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of mouse sPLA2-10
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Group 10 secretory phospholipase A2 (CHEMBL4200)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Design of Selective sPLA2-X Inhibitor (-)-2-{2-[Carbamoyl-6-(trifluoromethoxy)-1H-indol-1-yl]pyridine-2-yl}propanoic Acid.
Giordanetto F, Knerr L, Nordberg P, Pettersen D, Selmi N, Beisel HG, de la Motte H, Månsson Å, Dahlström M, Broddefalk J, Saarinen G, Klingegård F, Hurt-Camejo E, Rosengren B, Wikström J, Wågberg M, Brengdahl J, Rohman M, Sandmark J, Åkerud T, Roth RG, Jansen F, Ahlqvist M.
ACS Med Chem Lett (2018) 9 : 600 -605
PubMed 30034586 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC90 1 - -
IC50 1 7.12 7.12

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4215835 2 7.12

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4215835 IC50 = 75.0 nM 7.12
CHEMBL4215835 IC90 = 820.0 nM -