Assay Detail
Binding
CHEMBL4199784
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human Cx26 expressed in Escherichia coli LB2003 assessed as reduction in cell growth measured after 18 hrs
29
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Inhibition of Connexin Hemichannels by New Amphiphilic Aminoglycosides without Antibiotic Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.09 | 5.60 |
| Imax | 14 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4204676 | — | — | 2 | 5.60 |
| CHEMBL4205159 | — | — | 2 | 5.37 |
| CHEMBL4209017 | — | — | 2 | 5.31 |
| CHEMBL4210911 | — | — | 2 | 5.21 |
| CHEMBL4213413 | — | — | 2 | 5.21 |
| CHEMBL4213933 | — | — | 2 | 5.18 |
| CHEMBL4203134 | — | — | 2 | 5.12 |
| CHEMBL4209535 | — | — | 2 | 5.09 |
| CHEMBL4212437 | — | — | 2 | 5.08 |
| CHEMBL1384 | KANAMYCIN | 4.0 | 1 | 5.03 |
| CHEMBL4216863 | — | — | 2 | 4.89 |
| CHEMBL4215327 | — | — | 2 | 4.87 |
| CHEMBL4210382 | — | — | 2 | 4.87 |
| CHEMBL4214786 | — | — | 2 | 4.73 |
| CHEMBL4206024 | — | — | 2 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4204676 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4205159 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4209017 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4210911 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4213413 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4213933 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4203134 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4209535 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4212437 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL1384 | KANAMYCIN | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL4216863 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4215327 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL4210382 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL4214786 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL4206024 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4204676 | — | Imax | = | 94.0 | % | - |
| CHEMBL4213413 | — | Imax | = | 94.0 | % | - |
| CHEMBL4205159 | — | Imax | = | 94.0 | % | - |
| CHEMBL4209535 | — | Imax | = | 94.0 | % | - |
| CHEMBL4209017 | — | Imax | = | 94.0 | % | - |
| CHEMBL4213933 | — | Imax | = | 94.0 | % | - |
| CHEMBL4214786 | — | Imax | = | 99.0 | % | - |
| CHEMBL4216863 | — | Imax | = | 94.0 | % | - |
| CHEMBL4212437 | — | Imax | = | 99.0 | % | - |
| CHEMBL4203134 | — | Imax | = | 99.0 | % | - |
| CHEMBL4206024 | — | Imax | = | 99.0 | % | - |
| CHEMBL4210911 | — | Imax | = | 99.0 | % | - |
| CHEMBL4210382 | — | Imax | = | 99.0 | % | - |
| CHEMBL4215327 | — | Imax | = | 99.0 | % | - |