Assay Detail
Binding
CHEMBL4200092
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]glycine from NMDA receptor in rat cortical and hippocampal membranes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.41 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31344 | — | — | 1 | 6.77 |
| CHEMBL295718 | — | — | 1 | 5.70 |
| CHEMBL53914 | — | — | 1 | 5.40 |
| CHEMBL417544 | — | — | 1 | 4.60 |
| CHEMBL278097 | — | — | 1 | 4.57 |
| CHEMBL53744 | — | — | 1 | - |
| CHEMBL50784 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31344 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL295718 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL53914 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL417544 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL278097 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL53744 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL50784 | — | IC50 | > | 1000000.0 | nM | - |