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Assay Detail

CHEMBL4200305

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Functional
Growth inhibition of human RKO cells after 48 hrs by CCK-8 assay
16
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type RKO
Confidence 1 — Organism
Curated By Intermediate

Target

RKO (CHEMBL614879)
Type CELL-LINE
Organism Homo sapiens

Publication

Antitumor Activity of Diterpenoids from Jatropha gossypiifolia: Cell Cycle Arrest and Apoptosis-Inducing Activity in RKO Colon Cancer Cells.
Zhang CY, Zhang LJ, Lu ZC, Ma CY, Ye Y, Rahman K, Zhang H, Zhu JY.
J Nat Prod (2018) 81 : 1701 -1710
PubMed 30106289 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
GI 13 - -
IC50 3 5.22 5.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4213396 1 5.58
CHEMBL2402276 JATROPHONE 1 5.10
CHEMBL185 FLUOROURACIL 4.0 1 4.99
CHEMBL4217960 1 -
CHEMBL4206244 1 -
CHEMBL4217375 1 -
CHEMBL4212423 1 -
CHEMBL4212957 1 -
CHEMBL4208050 1 -
CHEMBL4209519 1 -
CHEMBL4204661 1 -
CHEMBL4205145 1 -
CHEMBL4216848 1 -
CHEMBL4210105 1 -
CHEMBL4215026 1 -
CHEMBL4214497 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4213396 IC50 = 2600.0 nM 5.58
CHEMBL2402276 JATROPHONE IC50 = 8000.0 nM 5.10
CHEMBL185 FLUOROURACIL IC50 = 10200.0 nM 4.99
CHEMBL4217960 GI - -
CHEMBL4206244 GI - -
CHEMBL4217375 GI - -
CHEMBL4212423 GI - -
CHEMBL4212957 GI - -
CHEMBL4208050 GI - -
CHEMBL4209519 GI - -
CHEMBL4204661 GI - -
CHEMBL4205145 GI - -
CHEMBL4216848 GI - -
CHEMBL4210105 GI - -
CHEMBL4215026 GI - -
CHEMBL4214497 GI - -