Assay Detail
Binding
CHEMBL4200409
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Reactivation of NIMP-inhibited human recombinant AChE assessed as dissociation constant of inhibited enzyme-compound complex incubated for 1 to 10 mins by spectrophotometry based Ellman's assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 4.56 | 4.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4216666 | — | — | 1 | 4.94 |
| CHEMBL3234588 | — | — | 1 | 4.70 |
| CHEMBL33051 | — | — | 1 | 4.05 |
| CHEMBL77510 | — | — | 1 | - |
| CHEMBL451635 | OBIDOXIME | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4216666 | — | Kd | = | 11500.0 | nM | 4.94 |
| CHEMBL3234588 | — | Kd | = | 20000.0 | nM | 4.70 |
| CHEMBL33051 | — | Kd | = | 90000.0 | nM | 4.05 |
| CHEMBL77510 | — | Kd | = | 210000.0 | nM | - |
| CHEMBL451635 | OBIDOXIME | Kd | = | 500000.0 | nM | - |