Assay Detail
Binding
CHEMBL4200426
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BRDT-BD1 (unknown origin) incubated for 1 hr by AlphaScreen biotin-JQ1 competition assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bromodomain testis-specific protein (CHEMBL1795185) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.13 | 6.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1957266 | — | — | 1 | 6.99 |
| CHEMBL4207437 | — | — | 1 | 6.99 |
| CHEMBL4216875 | — | — | 1 | 6.64 |
| CHEMBL4206381 | — | — | 1 | 6.61 |
| CHEMBL4216442 | — | — | 1 | 6.54 |
| CHEMBL4209902 | — | — | 1 | 6.47 |
| CHEMBL4202678 | — | — | 1 | 6.43 |
| CHEMBL4210414 | — | — | 1 | 6.42 |
| CHEMBL4210571 | — | — | 1 | 6.41 |
| CHEMBL4203571 | — | — | 1 | 6.25 |
| CHEMBL4213276 | — | — | 1 | 6.25 |
| CHEMBL4202820 | — | — | 1 | 6.12 |
| CHEMBL4212346 | — | — | 1 | 6.03 |
| CHEMBL4206052 | — | — | 1 | 6.01 |
| CHEMBL4209192 | — | — | 1 | 5.71 |
| CHEMBL3609305 | — | — | 1 | 5.45 |
| CHEMBL4205459 | — | — | 1 | 5.45 |
| CHEMBL4206171 | — | — | 1 | 5.07 |
| CHEMBL3609304 | — | — | 1 | 4.58 |
| CHEMBL4207347 | — | — | 1 | - |
| CHEMBL4212237 | — | — | 1 | - |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | - |
| CHEMBL4215910 | — | — | 1 | - |
| CHEMBL4214823 | — | — | 1 | - |
| CHEMBL4218106 | — | — | 1 | - |
| CHEMBL4207165 | — | — | 1 | - |
| CHEMBL4215729 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1957266 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL4207437 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL4216875 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL4206381 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL4216442 | — | IC50 | = | 289.0 | nM | 6.54 |
| CHEMBL4209902 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL4202678 | — | IC50 | = | 369.0 | nM | 6.43 |
| CHEMBL4210414 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL4210571 | — | IC50 | = | 392.0 | nM | 6.41 |
| CHEMBL4203571 | — | IC50 | = | 558.0 | nM | 6.25 |
| CHEMBL4213276 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4202820 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4212346 | — | IC50 | = | 933.0 | nM | 6.03 |
| CHEMBL4206052 | — | IC50 | = | 978.0 | nM | 6.01 |
| CHEMBL4209192 | — | IC50 | = | 1951.0 | nM | 5.71 |
| CHEMBL3609305 | — | IC50 | = | 3513.0 | nM | 5.45 |
| CHEMBL4205459 | — | IC50 | = | 3543.0 | nM | 5.45 |
| CHEMBL4206171 | — | IC50 | = | 8468.0 | nM | 5.07 |
| CHEMBL3609304 | — | IC50 | = | 25990.0 | nM | 4.58 |
| CHEMBL4207347 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4212237 | — | IC50 | - | — | - | |
| CHEMBL513909 | BI-2536 | IC50 | - | — | - | |
| CHEMBL4215910 | — | IC50 | - | — | - | |
| CHEMBL4214823 | — | IC50 | - | — | - | |
| CHEMBL4218106 | — | IC50 | - | — | - | |
| CHEMBL4207165 | — | IC50 | - | — | - | |
| CHEMBL4215729 | — | IC50 | - | — | - |