Assay Detail
Binding
CHEMBL4200615
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human plasma kallikrein using chromogenic L-pyroGlu-L-Pro-L-Arg-p-nitroaniline as substrate by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.87 | 4.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4213248 | — | — | 1 | 4.95 |
| CHEMBL4207715 | — | — | 1 | 4.78 |
| CHEMBL4217043 | — | — | 1 | - |
| CHEMBL501701 | N,N-HEXAMETHYLENEAMILORIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4213248 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL4207715 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL4217043 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL501701 | N,N-HEXAMETHYLENEAMILORIDE | IC50 | > | 50000.0 | nM | - |