Assay Detail
ADMET
CHEMBL4200628
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by CellTiter 96 Aqueous One solution cell proliferation assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.03 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL501701 | N,N-HEXAMETHYLENEAMILORIDE | — | 1 | 5.55 |
| CHEMBL4213248 | — | — | 1 | 5.51 |
| CHEMBL4207715 | — | — | 1 | 4.92 |
| CHEMBL4217043 | — | — | 1 | 4.13 |
| CHEMBL4212068 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL501701 | N,N-HEXAMETHYLENEAMILORIDE | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4213248 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4207715 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4217043 | — | IC50 | = | 74900.0 | nM | 4.13 |
| CHEMBL4212068 | — | IC50 | > | 100000.0 | nM | - |