Assay Detail
Functional
CHEMBL4200629
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Cytotoxicity against human HT1080 cells assessed as reduction in cell viability after 48 hrs by CellTiter 96 Aqueous One solution cell proliferation assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.00 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4207715 | — | — | 1 | 5.68 |
| CHEMBL4213248 | — | — | 1 | 5.34 |
| CHEMBL501701 | N,N-HEXAMETHYLENEAMILORIDE | — | 1 | 5.18 |
| CHEMBL4212068 | — | — | 1 | 4.43 |
| CHEMBL4217043 | — | — | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4207715 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4213248 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL501701 | N,N-HEXAMETHYLENEAMILORIDE | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4212068 | — | IC50 | = | 37100.0 | nM | 4.43 |
| CHEMBL4217043 | — | IC50 | = | 44800.0 | nM | 4.35 |