Assay Detail
Binding
CHEMBL4200690
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Binding affinity to transthyretin (unknown origin) by ITC method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 7.11 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103837 | TAFAMIDIS | 4.0 | 1 | 8.36 |
| CHEMBL3940890 | ACORAMIDIS | 4.0 | 1 | 8.32 |
| CHEMBL1324 | TOLCAPONE | 4.0 | 1 | 7.69 |
| CHEMBL4206443 | — | — | 1 | 7.05 |
| CHEMBL4210824 | — | — | 1 | 6.60 |
| CHEMBL4218173 | — | — | 1 | 6.59 |
| CHEMBL898 | DIFLUNISAL | 4.0 | 1 | 6.39 |
| CHEMBL4205939 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103837 | TAFAMIDIS | Kd | = | 4.4 | nM | 8.36 |
| CHEMBL3940890 | ACORAMIDIS | Kd | = | 4.8 | nM | 8.32 |
| CHEMBL1324 | TOLCAPONE | Kd | = | 20.6 | nM | 7.69 |
| CHEMBL4206443 | — | Kd | = | 90.0 | nM | 7.05 |
| CHEMBL4210824 | — | Kd | = | 251.0 | nM | 6.60 |
| CHEMBL4218173 | — | Kd | = | 258.0 | nM | 6.59 |
| CHEMBL898 | DIFLUNISAL | Kd | = | 407.0 | nM | 6.39 |
| CHEMBL4205939 | — | Kd | = | 1253.0 | nM | 5.90 |