Compound Detail
CHEMBL3940890
ACORAMIDIS 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL3940890 |
| Name | ACORAMIDIS |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | WBFUHHBPNXWNCC-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
3
Targets
7
Activities
2
Assay Types
0
PK Parameters
9
Publications
3
Known Names
3
Indications
1
Mechanisms
Molecular Properties
292.3
MW (Da)
2.88
ALogP
3
HBA
2
HBD
75.2
PSA (Ų)
0.80
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2024 |
| Availability | Prescription |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Transthyretin stabiliser | STABILISER | Transthyretin | ✓ | ✓ |
Indications
Amyloid Neuropathies, Familial Cardiovascular Diseases Amyloidosis
ATC Classification
C01EB25
acoramidis
Level 1: CARDIOVASCULAR SYSTEM
Level 2: CARDIAC THERAPY
Activity Summary
Kd 5 meas. best 8.32
IC50 2 meas. best 6.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transthyretin CHEMBL3194 | Kd | 8.32 | 7.82 | 4.8 | 4 |
| Transthyretin CHEMBL3194 | IC50 | 6.8 | 6.8 | 160.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.29 | 6.29 | 512.0 | 1 |
| Albumin CHEMBL3253 | Kd | 5.1 | 5.1 | 8000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transthyretin | Kd | = | 4.8 | nM | 8.32 | Binding affinity to human plasma wild type TTR assessed as dissociation constant... | 27020050 |
| Transthyretin | Kd | = | 4.8 | nM | 8.32 | Binding affinity to transthyretin (unknown origin) by ITC method | 30133284 |
| Transthyretin | Kd | = | 7.3 | nM | 8.14 | Binding affinity to human TTR incubated for 20 mins by fluorescence polarization... | 36327103 |
| Transthyretin | IC50 | = | 160.0 | nM | 6.8 | Binding affinity to human plasma TTR tetramer assessed as displacement of diclof... | 34138572 |
| Transthyretin | Kd | = | 314.0 | nM | 6.5 | Binding affinity to human plasma wild type TTR assessed as dissociation constant... | 27020050 |
| Unchecked | IC50 | = | 512.0 | nM | 6.29 | Disruption of retional-induced bacterially expressed MBP-tagged RBP4-TTR (unknow... | 34138572 |
| Albumin | Kd | = | 8000.0 | nM | 5.1 | Binding affinity to human serum albumin by ITC method | 30133284 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30133284 | 10.1021/acs.jmedchem.8b00817 | Transthyretin | 24 |
| 30133284 | 10.1021/acs.jmedchem.8b00817 | Canis familiaris | 5 |
| 30133284 | 10.1021/acs.jmedchem.8b00817 | Albumin | 3 |
| 27020050 | 10.1016/j.ejmech.2016.02.074 | Transthyretin | 2 |
| 30133284 | 10.1021/acs.jmedchem.8b00817 | No relevant target | 1 |
| 34138572 | 10.1021/acs.jmedchem.1c00099 | Unchecked | 1 |
| 34138572 | 10.1021/acs.jmedchem.1c00099 | Transthyretin | 1 |
| 34138572 | 10.1021/acs.jmedchem.1c00099 | Retinol-binding protein 4 | 1 |
| 36327103 | 10.1021/acs.jmedchem.2c01423 | Transthyretin | 1 |
Data from ChEMBL 36 via Core Engine