Assay Detail
Binding
CHEMBL5152785
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Binding affinity to human TTR incubated for 20 mins by fluorescence polarization assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Enhancing the Safety and Efficacy of PSMA-Based Small-Molecule Drug Conjugates by Linker Stabilization and Conjugation to Transthyretin Binding Ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.98 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3940890 | ACORAMIDIS | 4.0 | 1 | 8.14 |
| CHEMBL5205181 | — | — | 1 | 7.13 |
| CHEMBL5180672 | — | — | 1 | 6.35 |
| CHEMBL5174982 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3940890 | ACORAMIDIS | Kd | = | 7.3 | nM | 8.14 |
| CHEMBL5205181 | — | Kd | = | 74.3 | nM | 7.13 |
| CHEMBL5180672 | — | Kd | = | 447.8 | nM | 6.35 |
| CHEMBL5174982 | — | Kd | = | 506.6 | nM | 6.29 |