Assay Detail
Binding
CHEMBL5033187
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Disruption of retional-induced bacterially expressed MBP-tagged RBP4-TTR (unknown origin) protein-protein interaction measured by d2 dye based HTFR assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of Transthyretin Tetramer Kinetic Stabilizers That Are Capable of Inhibiting the Retinol-Dependent Retinol Binding Protein 4-Transthyretin Interaction: Potential Novel Therapeutics for Macular Degeneration, Transthyretin Amyloidosis, and Their Common Age-Related Comorbidities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.67 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3940890 | ACORAMIDIS | 4.0 | 1 | 6.29 |
| CHEMBL5082796 | — | — | 1 | 6.23 |
| CHEMBL5080175 | — | — | 1 | 6.07 |
| CHEMBL2103837 | TAFAMIDIS | 4.0 | 1 | 6.01 |
| CHEMBL5091368 | — | — | 1 | 5.76 |
| CHEMBL5089170 | — | — | 1 | 5.58 |
| CHEMBL5080942 | — | — | 1 | 5.45 |
| CHEMBL5093498 | — | — | 1 | 5.02 |
| CHEMBL5085751 | — | — | 1 | 4.62 |
| CHEMBL5078773 | — | — | 1 | - |
| CHEMBL5090952 | — | — | 1 | - |
| CHEMBL5091475 | — | — | 1 | - |
| CHEMBL5081258 | — | — | 1 | - |
| CHEMBL5089791 | — | — | 1 | - |
| CHEMBL5082364 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3940890 | ACORAMIDIS | IC50 | = | 512.0 | nM | 6.29 |
| CHEMBL5082796 | — | IC50 | = | 583.0 | nM | 6.23 |
| CHEMBL5080175 | — | IC50 | = | 845.0 | nM | 6.07 |
| CHEMBL2103837 | TAFAMIDIS | IC50 | = | 981.0 | nM | 6.01 |
| CHEMBL5091368 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL5089170 | — | IC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL5080942 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL5093498 | — | IC50 | = | 9580.0 | nM | 5.02 |
| CHEMBL5085751 | — | IC50 | = | 24010.0 | nM | 4.62 |
| CHEMBL5078773 | — | IC50 | - | — | - | |
| CHEMBL5090952 | — | IC50 | - | — | - | |
| CHEMBL5091475 | — | IC50 | - | — | - | |
| CHEMBL5081258 | — | IC50 | - | — | - | |
| CHEMBL5089791 | — | IC50 | - | — | - | |
| CHEMBL5082364 | — | IC50 | - | — | - |